Name: Alina Hua

Theme: Lipoprotein Metabolism

 

OPTION LIST

 

A	Atorvastatin	I
B	Omega-3 fatty acid compounds	J
C	Bezafibrate	K
D	Gliclazide	L
E	Anti-PCSK9 antibodies	M
F	Gastric banding	N
G	Roux-en-Y gastric bypass	O
H	Do nothing	P

 

 

Choose the most appropriate lipid- modifying drug or procedure given the scenarios below. Each option may be used once, more than once or not at all.

 

 

1. 15 year old patient presents to the GP for a routine check-up. On examination, the GP notices xanthelasma and corneal arcus. What is the first-line treatment for this patient?

 

2. 54 year old female presents to her GP with high levels of cholesterol on a routine blood test. Of note, she has been experiencing weight gain, cold-intolerance and lethargy. She was also diagnosed with hypothyroidism on this ocassion.

 

3. 60 year old man, with controlled type II diabetes mellitus has a total cholesterol level of 8.5 mmol/L.

 

4. 65 year old female goes to the GP for a routine check up and was found to have raised total cholesterol 8.0 mmol/L.

 

5. 48 year old man with a BMI of 36 was admitted to the hospital a year ago with acute myocardial infarction. He now presents to the GP with a raised total cholesterol of 8.0mmol/L. On further questioning, he complained of severe rash and pruritis, which stopped when he discontinued his statin treatment.

 

 

ANSWERS

1. A

2. H

3. A

4. H

5. C

 

 

NB: Patients with hypothyrodism should receive adequate thyroid replacement therapy before assessing the requirement for lipid-regulating treatment because correcting hypothyroidism itself may resolve the lipid abnornality.