Pathology EMQ template.

Name: Lin Lu

Theme: Obesity & cardiovascular update

 

OPTION LIST

 

A	Aβ-lipoproteinaemia	I	Secondary hyperlipidaemia
B	Familial hypoα-lipoproteinaemia	J	Secondary hypolipidaemia
C	Familial hypoβ-lipoproteinaemia	K	Secondary hypothyroidism
D	Hashimoto’s thyroiditis	L	Type I primary hyperlipidaemia
E	HDL receptor	M	Type II primary hyperlipidaemia
F	LDL receptor	N	Type III primary hyperlipidaemia
G	Microsomal triglyceride transport protein (MTP)	O
H	Phytosterolaemia	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. An 8 years old boy presents to his GP with corneal arcus and xantholasmata. Blood test shows increased serum cholesterol and triglycerides. Biochemical phenotyping reveals broad β band. Under Fredrickson classification, he has:

 

 

2. A 53 years old lady complains of weight gain, tiredness and dry cold skin. TFTs shows increased TSH and decreased T4; test also revealed a reduction of LDLR functions. What is the most likely diagnosis?

 

 

3. ApoE3/3 polymorphism is the commonest in this dyslipidiaemia condition:

 

 

4. Mutation of ABC (ATP-binding cassette) transporters G5 and G8 can cause:

 

 

5. Heterozygous inheritance of apoA-1 mutation can cause:

 

 

 

ANSWERS

1. N

2. I

3. N

4. H

5. B