Pathology EMQ template.

Name: Aysha Rashid

Theme: Therapeutic Drug Monitoring

 

OPTION LIST

 

A	Allopurinol	I	Erythromycin
B	Aspirin	J	Gentamicin
C	Atorvastatin	K	Infliximab
D	Beryllium	L	Lithium
E	Codeine	M	Paracetamol
F	Cyclosporin	N	Phenytoin
G	Digoxin	O	Theophylline
H	Doxycycline	P	Tioguanine

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. Check patient’s TPMT (thiopurine methyltransferase) activity before starting them on this drug.

 

 

2. There are large individual variations in metabolism of this drug by CYP2C9 in the liver, and the patient should be monitored for at least two weeks after a dosage change until a steady state is reached.

 

3. Symptoms of undertreatment and toxicity may be similar with this drug, which the body is more sensitive to in hypomagnesia.

 

4. Ototoxicity and nephrotoxicity are serious side-effects of this drug.

 

 

5. Toxicity with this drug can, in extreme cases, lead to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death.

 

 

ANSWERS

1.

2.

3.

4.

5.