Pathology EMQ template.

Name: Jack Reid

Theme: Thrombosis

 

OPTION LIST

 

A	Activated Factor X	I	Protein S
B	Factor V	J	Prothrombin
C	Factor VII	K	Streptokinase
D	Factor XI	L	Thrombin
E	Fibrinogen	M	Thromboxane A2
F	Lupus Anticoagulant	N	Tissue Factor
G	Nitric Oxide	O
H	Prostacyclin	P

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. This cell surface proteins expression is upregulated on malignant cells and plays a key role in the initiation of the extrinsic coagulation cascade.

 

2. A variant of this protein rendering it insensitive to protein C inactivation is the cause of the most common hereditary hypercoagulability disorder.

 

3. This immunoglobulin increases the risk of arterial thrombosis, venous thrombosis and miscarriages.

 

4. This substance when produced by enzymes in the endothelium inhibits platelet activation and induces smooth muscle relaxation.

 

5. This coagulation inhibiting glycoprotein which is downregulated in pregnancy, normally it exerts its anticoagulant activity by acting as a cofactor to protein C.

 

ANSWERS

1. N

2. B

3. F

4. G

5. I