Pathology EMQ template.

Name: Naveen Setty

Theme: Uric Acid Metabolism

 

OPTION LIST

 

A	Xanthine Oxidase	I	Psuedogout
B	5 – phosphoribosyl – 1 – pyrophosphate (PRPP)	J	Thiazide Diuretics
C	Hypoxanthine guanosine phosphoribosyltransferase (HPRT)	K	Familial juvenile hyperuricaemic nephropathy (FJHN)
D	PPRP amidotransferase (PAT)	L	Carcinomatosis
E	Uricase	M	Gaucher’s Disease
F	Adenine phosphoribosyltransferase (APRT)	N
G	Lesch Nyhan Syndrome	O
H	Gout	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. The rate limiting enzyme in purine metabolism.

 

 

2. Primarily responsible for the salvage pathway.

 

 

3. A 60 year old builder presents with an acute, severe pain in his wrist. He states that he normally has a milder pain in that and other joints. Aspiration shows positively birefringent crystals.

 

 

4. A young boy is brought in by his mother complaining of pain in his hand. Routine bloods show his creatinine to be mildly elevated and on questioning, it is revealed his father had similar symptoms at a young age.

 

 

5. An obese 65 year old man, with a history of essential hypertension, presents with an acute onset of a painful, swollen first metatarsophalangeal joint on his right hand.

 

 

 

ANSWERS

1. D

2. C

3. I

4. K

5. J