Pathology EMQ template.

Name: Alexander Wijnberg 

Candidate number:

Theme: Immune Therapies

 

OPTION LIST

 

A	Abatacept	I	Rituximab
B	Azathioprine	J	Sirolimus
C	Cyclophosphamide	K	Tacrolimus
D	Cyclosporin	L	Ustekinumab
E	Infliximab	M
F	Methotrexate	N
G	Natalizumab	O
H	Prednisone	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. This pro-drug is metabolised by the liver into 6-mercaptopurine which blocks purine synthesis.

 

 

2. This calcineurin inhibitor is associated with significant gingival hyperplasia.

 

 

3. This agent binds the immunophillin FKPB and impairs IL-2 receptor signal transduction.

 

 

4. This agent is used in MS and Crohn’s disease where it prevents migration of leukocytes to sites of inflammation by binding α4 intergrins.

 

 

5. This agent binds CD-20, so depleting mature B-cells.

 

 

ANSWERS

1. B

2. D

3. J

4. G

5. I