Pathology EMQ

Name: David Yousefi Azimi

Theme: Liver and Biliary disease

 

OPTION LIST

 

A	Budd-Chiari syndrome	I	Lucey-Driscoll syndrome
B	Cholestasis	J	Rotor syndrome
C	Crigler-Najjar syndrome type I	K	Viral Hepatitis
D	Crigler-Najjar syndrome type II	L	Wilson’s disease
E	Dubin-Johnson syndrome	M
F	Gilbert’s syndrome	N
G	Haemochromatosis	O
H	Haemolysis	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A post-mortem biopsy of a man revealed an elevated level of conjugated bilirubin, a urine coproporphyrin I to coproporphyrin III ratio of 3-4:1, and a dark pink or black liver.

 

2. A young man, offspring of first degree cousins, presented with unconjugated bilirubin between 100-345 µmol/L, pigmented bile, but without kernicterus (bilirubin encephalopathy).

 

3. A middle-aged man presented with jaundice that appeared on numerous occasions under conditions of exertion, stress, fasting, or infections, was found to have reduced glucuronyltransferase activity, and was later told by the doctors to have a significantly decreased risk of coronary artery disease as a result.

 

4. A 45 year old man with hypopituitarism, cardiomyopathy, diabetes, and arthritis got anxious when he noticed hyperpigmentation on his abdomen, and consequently booked an appointment to see his GI specialist who had recently diagnosed him with hepatic cirrhosis.

 

5. A tired, clumsy 13 year old boy recently started to develop Parkinson-like symptoms at the same time as being told he had abnormal liver function tests.

 

 

 

ANSWERS

1. E

2. D

3. F

4. G

5. L