Pathology EMQ template.

Name: Sophie Chambers

Theme: Chronic Myeloid Leukaemia – treatment

 

 

OPTION LIST

 

A	Corticosteroids	I	Stem cell transplantation
B	Supportive care	J	Plasma exchange
C	Splenectomy	K	Rituximab
D	Chlorambucil	L	Allogenic bone marrow transplantation
E	Imatinib Mesilate	M
F	Oral hydroxycarbamide	N
G	Dasatinib	O
H	Cyclophosphamide	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. If a patient has been diagnosed with BCR –ABL positive chronic phase CML – which drug are they usually trialled on initially?

 

2. Which treatment/drug would be the next line if a patient failed on Imatinib therapy?

 

3. Which treatment/drug can help control the proliferative features of CML?

 

4. Which treatment/drug can be used for potentially curative purposes with chronic phase CML?

 

5. Which treatment/drug acts on BCR/ABL, Src, c-Kit, ephrin receptors, as well as several other tyrosine kinases?

 

 

ANSWERS

1. E

2. G

3. F

4. L

5. G