Pathology EMQ template.

Name: Marie Houdmont

Theme: Immune therapies

 

OPTION LIST

 

A	Abatacept	I	Mycophenolate Mofetil
B	Antibody replacement therapy	J	Plasmapheresis
C	Azathioprine	K	Prednisolone
D	Bone Marrow Transplant	L	Varicella zoster immunoglobulin
E	Ciclosporin	M
F	Denosumab	N
G	Etarnacept	O
H	IFN gamma	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A 2 month old child presents with recurrent infections, failure to thrive, persistent diarrhoea and reticular dysgenesis (low neutrophil, lymphocytes, macrophage, platelets). What is the treatment of choice?

 

 

2. A young boy presents with recurrent respiratory tract infections and otitis media. His uncle suffered similarly in childhood. On investigation a defect in B cell maturation is seen. Which treatment is the most appropriate for x-linked agammaglobulinaemia?

 

 

3. A 63 year old man received a renal transplant 5 years ago. He has now started to develop herpes infections and on recent investigations bone marrow suppression is seen. Which drug is responsible?

 

 

4. TNFa inhibitor used in ankylosing spondylitis. It may cause lupus-like syndromes and demyelination as a side effect. It is given weekly in subcutaneous injections

 

 

5. A 74 year old lady present with a hip fracture – severe osteoporosis is suspected. Which drug should be prescribed?

 

 

ANSWERS

1. D

2. B

3. I

4. G

5. F