Pathology EMQ template

Name: Hayley Jones

Theme: Liver and Biliary Disease

 

OPTION LIST

 

A	ALT	I	α-1 antitrypsin
B	γGT	J	Caeroplasmin
C	Bilirubin	K	IgA
D	Urobilinogen	L	IgG
E	Haptoglobin	M	IgM
F	Alkaline phosphatase (ALP)	N	AFP
G	Cholesterol	O	β-HCG
H	Creatinine	P	Ca15.3

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A 57 yr old male presents with painless jaundice and weight loss. o/e he is Courvoisier’s sign +ve. Which liver enzyme will be most elevated on blood LFT’s.

 

 

2. A 30yr old female presents to A&E with jaundice, pruritis and xantholesmas around the eyes. On blood tests ALP is raised and serum is AMA+ve. Liver biopsy shows bile duct destruction, granulomas and fibrosis. Which immunoglobulin would you expect to see in high titre on serology?

 

 

3. This serum protein is synthesised in the liver and immediately secreted into the blood, where it has anti-proteolytic properties. Homozygous states are associated with a predisposition to pulmonary emphysema and hepatic cirrhosis.

 

 

4. Present on urine dipstick in the normal individual

 

 

5. A rapidly rising level of this protein during haemolysis can cause kernicterus in neonates.

 

 

 

 

ANSWERS

1. F

2. M

3. I

4. D

5. C