Pathology EMQ template.

Name: Sarah Kennie

Theme: Lymphoma

 

OPTION LIST

 

A	Germinal Center B Cell-Like diffuse large B-cell lymphoma	I	MALT lymphoma
B	Mantle cell lymphoma	J	NK-cell lymphoma
C	Marginal zone lymphoma	K	Primary mediastinal B-cell lymphoma
D	Follicular NHL	L
E	Burkitt’s lymphoma	M
F	Lymphoblastic lymphoma	N
G	Activated B Cell-Like diffuse large B-cell lymphoma	O
H	Small lymphocytic lymphoma	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. Constitutive activation of nuclear factor κ B target genes distinguishes this subtype of diffuse large B-cell lymphoma (observed in cell lines).

 

 

2. The t(11;14)(q21;q21) translocation is associated with a poor response to therapy in one subtype of NHL (which is also associated with a lack of ‘B’ symptoms).

 

 

3. The t(14;18)(q32;q21) translocation (BCL-2 gene) distinguishes this subtype of diffuse large B-cell lymphoma.

 

 

4. Another NHL involving BCL-2 overexpression.

 

 

5. C-MYC overexpression is associated with this NHL.

 

 

ANSWERS

1. G

2. I

3. A

4. D

5. E