Pathology EMQ template.

Name: Christina Lees          

Theme: Myelodysplastic syndromes

 

OPTION LIST

 

A	Refractory anaemia	I	Juvenile chronic myelomonocytic leukaemia
B	Refractory anaemia with ringed sideroblasts	J	Therapy-related MDS
C	Refractory cytopenia with multilineage dysplasia	K
D	Refractory anaemia with excess blasts-1	L
E	Refractory anaemia with excess blasts-2	M
F	MDS associated with isolated del(5q)	N
G	Myelodysplastic syndrome unclassified	O
H	Chronic myelomonocytic leukaemia-1	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. persistent monocytosis of >1 x 10 /L with splenomegaly and a skin rash

 

 

2. findings on examination of bone marrow include: <5% blasts, megakaryocytes with hypolobulated nuclei. The cytogenetic abnormality has a good prognosis. This patient was then started on lenalidomide

 

 

3. 5-19% blasts in peripheral blasts and 10-19% blasts in bone marrow. Has a poor prognosis

 

 

4. 3 year old child with hepatosplenomegaly and lymphodenopathy, blood tests revealed increased haemoglobin F for his age, and a monocytosis >1 x 10

 

 

5. bone marrow findings: erythroid dysplasia with <15% ringed sideroblasts

 

 

 

ANSWERS

1. h

2. f

3. e

4. i

5. a