Pathology EMQ template.

Name: Huy Nguyen

Theme: Pathology of HIV/AIDS

 

OPTION LIST

 

A	gp120	I	MIP-1α
B	gp41	J	SDF-1
C	p24gag	K
D	CCR5	L
E	CD3	M
F	CD4	N
G	CD8	O
H	CXCR4	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A beta chemokine co-receptor molecule, encoded on chromosome 3, that is found on CD4+ T cells. Many forms of HIV use this molecule to initially enter and infect host CD4+ T cells.

 

 

2. Antibodies to this transmembrane glycoprotein (which becomes exposed in the second stage of HIV entry into host CD4+ T cells) have shown importance in protective immunity against HIV.

 

 

3. A glycoprotein expressed on the surface of T helper cells that binds to gp120, after which a conformational change occurs to permit the next step in viral-cell membrane fusion.

 

 

4. The natural chemokine to CCR5 have been shown to suppress HIV-1 infection in vitro.

 

 

5. A capsid protein that is recognised by HLA class II molecules, and is important in conferring acquired immunity in CD4+ T cells.

 

 

 

ANSWERS

1. D

2. B

3. F

4. I

5. C