Pathology EMQ template.

Name: Patel, Jennifer

Theme: Immunodeficiency

 

OPTION LIST

 

A	IgA	I	CD4 T cell tyrosine kinase
B	IgM	J	C2
C	IgG	K	Lectin
D	IL-12 receptor	L	Factor I
E	Neutrophil elastase (ELA2)	M	HLA class I molecule
F	CD40	N	HLA class II molecule
G	CD18	O
H	B cell tyrosine kinase	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A 3 yr old boy presents to the GP because his parents are concerned that he is “picking up a new infection every month or so”. His mother recalls that she also suffered from repeated infections as a child but that these declined in frequency in her teens. In which gene is the likely mutation causing the boy’s condition?

 

2. A 25 yr old female presents to hospital after a serious RTA and is immediately transfused 1L of O-ve blood. Soon after the transfusion she begins to show signs of anaphylaxis. A deficiency in what may be responsible for this reaction?

 

3. Unless immunosuppressed, a deficiency in this is rarely associated with any symptoms.

 

4. A young child presents to hospital after suffering a severe skin reaction in response to the BCG vaccination a few weeks earlier. A problem with which of the above could have led to this reaction?

 

5. A 5 month old baby presents to A and E with a severe respiratory infection. Blood results show a distinct lack of antibodies with a corresponding low B cell but normal T cell count. A defect in what is the likely cause of this condition?

ANSWERS

1. E

2. A

3. K

4. D

5. H