Pathology EMQ template.

Name: Verena Byrne (Skinner)

Theme: Uric Acid Metabolism

 

OPTION LIST

 

A	Hypoxanthine-guanine Phosphoribosyl Transferase	I	Xanthine Oxidase
B	Gout	J
C	Lesch-Nyhan Syndrome	K
D	Monosodium Urate	L
E	Pseudogout	M
F	Pyrophosphate	N
G	Urate	O
H	Xanthine	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A young child with hyperuricaemia, abnormal development and repeated tongue-biting is found to have which enzyme deficiency.

 

2. A tap effusion showing crystals that are positively birefringent under polarised light is indicative of what diagnosis.

 

3. These crystals are viewed under polarised light with a red plate, and those in the plane of the long axis are yellow.

 

4. Hypoxanthine-guanine Phosphoribosyl Transferase deficiency is found in which cause of hyperuricaemia.

 

5. This enzyme is involved in the conversion of guanine to guanylic acid.

 

 

 

ANSWERS

1. A

2. E

3. D

4. C

5. A­­­