Pathology EMQ template

Name: Alice Snell

Theme: Uric Acid Metabolism

 

OPTION LIST

 

A	Allantoin	I	Inosine
B	Allopurinol	J	PNP (purine nucleoside phosphorylase)
C	Ankylosing Spondylitis	K	Probenecid
D	Aspirin	L	PRPP synthase (phosphoribosyl pyrophosphate synthase)
E	Ciclosporin	M	Pseudogout
F	Colchicine	N	Tacrolimus
G	Gout	O	Xanthine
H	HGPRT (hypoxanthine-guanine phosphoribosyltransferase)	P	Xanthine Oxidoreductase

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. Which drug used in the treatment of gout, decreases neutrophil function?

 

 

2. The overactivity of which enzyme causes hyperuricaemia?

 

 

3. What is the product of uric acid degradation by uricase?

 

 

4. Which drug increases renal excretion of uric acid?

 

 

5. Positively birefringent crystals under polarized light is diagnostic of which condition?

 

 

ANSWERS

1. F

2. L

3. A

4. K

5. M