Pathology EMQ template.

Name: Lindsay Hayden         

Theme: Enzymology

OPTION LIST

A	Alanine aminotransferase	I	Troponin T
B	Aspartate aminotransferase	J
C	BB isoenzyme of CK	K
D	Creatinine phosphokinase	L
E	Cystathionine synthetase	M
F	Lactate dehydrogenase	N
G	MM isoenzyme of CK	O
H	Phenylalanine hydroxylase	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. An 18 year old male construction worker has a wall collapse on him. The fire department have been trying to release him for the past several hours. He begins to feel nauseous and is constantly retching. Which enzyme will be elevated?

2. A 20 year old male with mild mental retardation has had two successive strokes within a year. On examination he had a marfinoid habitus (ie long limbs and pectus excavatum). What is the most likely enzyme defect?

3. A middle eastern male child with fair complexion adopted a soon after his premature birth is noted to have delayed milestones at 8 months of age. He is also noted to have eczema. At two years of age the child has severe mental retardation with no pyramidal or extra-pyramidal signs. Mental retardation in this child is likely to be due to a defect in which enzyme?

4. Which enzyme regulated Ca-mediated contractile process of striated muscle and is most specific for minor degrees of myocardial necrosis?

5. Which enzyme occurs in high concentration in sarcoplasm of skeletal muscle?

ANSWERS

1. D

2. E

3. H

4. I

5. C