Name: David Hillier     

Theme: Fungal Infection

OPTION LIST

A	Amophotericin B	I	Echinocandins
B	Aspergillosis	J	Fluconazole
C	Blastomycosis	K	Histoplasmosis
D	Candida endophthalmitis	L	Pulmonary cryptococcal infection
E	Candida tropicalis	M	Seborrhoeic dermatitis
F	Cryptococcosis neoformans	N	Voriconazole
G	Cryptococcus gattii	O	Zygomyces
H	Dermatophyte

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all. 

1. A young infant has generalized candidiasis with notable involvement of body creases (groin, axillae, neck, cubital fossae). What is this secondary to?

2.  48 year old lady presents to A&E with fever, fatigue, vomiting, headache, confusion and neck stiffness. Her notes reveals that she is HIV positive. A lumbar puncture was performed. Which organism was revealed on examination of the CSF?

3. 83 year old man, who wears dentures, presents with thick white deposits on his oral mucous membranes.  Microscopy shows the organism is Candida albicans. What anti-fungal drug should he be started on?

4. 41 year old man recently had a stem cell transplant.  A CT scan of his thorax showed several nodules demonstrating the “halo sign”.  What condition does this CT scan suggest?

5.   This antifungal works by stimulating cell death. It does this by creating pores in the cell membrane, causing leakage of electrolytes and cytoplasm.

ANSWERS

1. M

2. F

3. J

4. B

5. A