Pathology EMQ

Name: Chao Kowa

Theme: Immune response to infection 1

OPTION LIST

A	b (1,3) glucan	I	Lactoferrin
B	Dermatan sulphate	J	Liposaccharide
C	Fibromodulin	K	Mycobactin
D	Granzyme	L	Mycolic acid
E	Heparan sulphate proteoglycan	M	Opsonin
F	Hepcidin	N	Perforin
G	Hyaluronan	O	Teichoic acid
H	Hydrochlorous acid	P	Uric acid

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A compound found in its highest concentration in colostrum, which exerts antiviral effects by binding to cell surface lipoproteins. It also exerts antibacterial effect via sequestering free iron and prevents the development of biofilms in cystic fibrosis.

2. An efficacious biological oxidant defending against microbial invasion.

3. A substance found on the cell wall of gram-positive bacteria which binds to C3, eventually leading to the formation of the membrane attack complex.

4. Found in the granules of CD8+ T cells, this compound exerts direct cytotoxic effects by insertion into the plasma membrane of the target cell and formation of a pore.

5. Recognised by Natural Killer cells, this group of compounds is found in the cell membrane and extracellular matrix. Members of this family include syndecan and betaglycan.

ANSWERS

1. I

2. H

3. O

4. N

5. E