Pathology EMQ.

Name: Matthew Leahy

Theme: Immune therapy

OPTION LIST

A	Abatacept	I	Ustekinumab
B	Basiliximab	J
C	Cyclophosphophamide	K
D	Denosumab	L
E	Efalizumab	M
F	Infliximab	N
G	Mycophenolate mofetil	O
H	Rituximab	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 56 year old Afro-Caribbean with known systemic lupus erythematous has been treated with long-term steroids. The patient presents to her rheumatologists with back pain, a DEXA scan confirms osteoporosis.

2. A 53 year old man who is undergoing kidney transplant surgery is given a drug that prevents guanine synthesis to induce immunosuppression.

3. A 60 year old woman who suffers from Rheumatoid arthritis is treated with methotrexate. Despite this, it becomes more severe. Her rheumatologist recommends a CTl4-immunoglobulin fusion protein.

4. A 48 year old man with longstanding SLE is seen by his rheumatologists. He is currently being treated with corticosteroids and has developed end-organ involvement of kidneys, lungs and heart.

5. A 54 year old who suffers from rheumatoid arthritis is seen by her rheumatologists. She has been taking disease modifying anti-rheumatic drugs, but her condition has recently worsened. As a result the doctor prescribes a TNF-a inhibitor.

ANSWERS

1. D

2. G

3. A

4. C

5. F