Pathology EMQ template.

Name: Weiran Liu

Theme: Lipoprotein Metabolism

OPTION LIST

A	Apo A1	I	PCSK9
B	Apo B	J
C	Apo C	K
D	Apo D	L
E	Apo E	M
F	CETP	N
G	HMG-CoA Reductase	O
H	LDLRAP1	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. Is found in VLDL and chylomicrons, and activates lipoprotein lipase in the capillaries

2. Is the main apolipoprotein of LDL and chylomicrons, leading to heart disease if deficient

3. Binds to LDL receptor to promote degradation, loss of function of which leads to low LDL levels

4. Class of apolipoprotein that is produced by astrocytes in the CNS, polymorphisms of which are associated with Parkinsons’ and Alzheimer’s Disease

5. Major factor of High Density Lipoprotein, mutation of which can lead to a paradoxical drop in HDL concentration and a reduction in atheroma in animal models

ANSWERS

1.C

2. B

3. I

4. E

5. A