Pathology EMQ template.

Name: Alexandra Nowbar

Theme: Myeloproliferative disorders

OPTION LIST

A	Hepatomegaly	I	t(11;14) translocation
B	High Hb, WCC and platelets	J	t(8;14) translocation
C	High platelet count	K	t(8;21) translocation
D	High WCC	L	t(9;21) translocation
E	Low Hb, WCC and platelets	M	t(9;22) translocation
F	Low platelet count	N	Teardrop erythrocytes
G	Spherocytes	O
H	Splenomegaly	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 65 year old man complains of headaches, dizziness and itching after getting out of the shower. On examination he is plethoric. What finding would confirm the diagnosis?

2. A 79 year old lady with splenomegaly is on imatinib. What abnormality is FISH (fluorescence in situ hybridisation) likely to reveal?

3. A 42 year old man presents fever, weight loss, night sweats and abdominal discomfort. Hepatosplenomegaly is noted on examination. The blood film shows leukoerythroblastic cells. What other blood abnormality may be present?

4. Headaches, transient ischaemic attacks and deep vein thrombosis are best explained by which abnormality?

5. A 50 year old lady presents with headaches and hepatosplenomegaly. The blood film shows megakaryocyte proliferation. What is the full blood count likely to reveal?

ANSWERS

1. B

2. M

3. N

4. C

5. C