\Pathology EMQ template.

Name: Suzanne Bradnum-Williams

Candidate number:

Theme: Coagulation

OPTION LIST

A	a2 macroglobulin	I	Fibrinogen
B	ADP	J	Megakaryocyte
C	Antithrombin III	K	Plasmin
D	Cycloxygenase	L	Platelet
E	Endothelial cell	M	Protein C
F	Erythrocyte	N	Thrombin
G	Factor VIIIa	O	Thromboxane A2
H	Fibrin	P	Tissue plasminogen-activator (t-PA)

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. The most important cell in the initiation of normal haemostasis.

2. The main component involved in stabilising the primary haemostatic plug.

3. A serine protease which assists in the break down of blood clots by binding to the clot and localising agents which break it down.

4. A potent inhibitor of plasmin in the blood.

5. A single chain glycoprotein, synthesised by the liver and endothelium, which has strongly anticoagulant action and is important in the mode of action of heparin.

ANSWERS

1. E

2. H

3. P

4. A

5. C