Pathology EMQ template.

Name: Zara Ioannides

Theme: Lipoproteins

OPTION LIST

A	Alcoholism	I	lipoproteins
B	Antibiotics	J	Myocardial infarction
C	Diabetes mellitus	K	pancreatitis
D	Familial combined hyperlipidaemia	L	progestogens
E	Familial hypertriglyceridaemia	M	Total cholesterol
F	Hypothyroidism	N	Triglyceride
G	Hyperthyroidism	O
H	LDL	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. These consist of a non-polar core of triglyceride and cholesterol esters surrounded by a surface layer of phospholipids, cholesterol and proteins (apolipoproteins).

2. This condition may arise as a result of longstanding primary hypertriglyceridaemia characterised by severe abdominal pain and the following plasma levels: Cholesterol 7.3 mmol/L (<4.5), triglyceride 34.0 mmol/L (<1.7), serum amylase 525 U/L (<300).

3. These drugs are known to have an adverse effect on the plasma lipid profile.

4. This condition is an important cause of secondary hyperlipidaemia in which there is a decrease in LDL receptor activity. It may present as raised cholesterol in a 55 year old female with weight gain and hoarse voice.

5. This condition is inherited as autosomal dominant and is associated with an increased hepatic synthesis of VLDL, obesity and insulin resistance.

ANSWERS

1. I

2. K

3. L

4. F

5. E