Your Name: James Franklin

Theme: Therapeutic drug monitoring

OPTION LIST

A

Rosiglitazone

I

Oxidation by cytochrome P450

B

Warfarin

J

Conjugation with sulphate/gluconaride

C

Digoxin

K

Kidneys

D

Theophylline

L

Liver

E

Gentamicin

M

Lungs

F

Poor compliance

N

GI system

G

High therapeutic index

O

  

H

Low therapeutic index

P

  

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 19 year old woman admitted to hospital with acute asthma suffered a cardiac arrest after treatment. She was already taking several medications for her respiratory condition. What drug excess is likely to have caused this problem?

 

2. Failure to respond to drug therapy is commonly caused by what?

 

3. Lipid soluble drugs require metabolism by the liver in two phases. What is Phase I

 

4. Drugs are mainly excreted by which organ?

 

5. The effect of which drug can be measured by the surrogate marker HbA1C

 

6. A 58 year old man presents to your A&E complaining of chest pain and palpitations. He says he takes several drugs for ‘heart problems’ and admits to being diabetic. What drug could be causing his problems.

 

ANSWERS

1. D

2. F

3. I

4. A

5. C