Name: Etienne Laverse
Theme: Liver Disease
OPTION LIST
|
A |
Budd-Chiari
Syndrome |
I |
|
|
B |
Chronic
hepatitis B |
J |
|
|
C |
Chronic
Hepatitis C |
K |
|
|
D |
Crigler-Najjar
Syndrome |
L |
|
|
E |
Hepatitis
A |
M |
|
|
F |
Primary
Biliary Cirrhosis |
N |
|
|
G |
Primary
Hepatocellular Carcinoma |
O |
|
|
H |
Wilson’s
Disease |
P |
|
For each scenario below, choose the most appropriate
answer from the list above. Each option may be used once, more than once or not
at all.
1. A 14yr old boy presents with symptoms
of chronic liver failure. LFTs display abnormally high levels of transaminases
with normal alk phos & bilirubin levels. There’s marked accumulation of
copper-associated protein in hepatocytes obtained from a biopsy. His serum
copper levels and caeruloplasmin are abnormally low.
2. A 30yr old Thai male presents to a
day surgery unit for a cholecystectomy. His LFTs reveal very elevated
transaminases with normal bilirubin & alk phos levels. Microscopy of a
liver biopsy identifies antigens from a dsDNA virus in the cytosol of
hepatocytes.
3. A 58yr old woman presents with
recent onset of Jaundice. LFTs reveal increased bilirubin & markedly
elevated alk phos & normal transaminases. Further
investigations uncovered raised IgM & serum cholesterol. Anti mitochondrial
antibodies are also detected. A liver biopsy shows enlargement of the portal
tracts by white blood cells and granulomas. Bile ducts are also less than
normal.
4. A 48yr old male returning from a 6mths round the world trip presents with a
recent Hx of nausea, anorexia & distaste for cigarettes. He developed jaundice;
his urine became dark and his stools pale. His spleen was palpable.
Investigations showed bilirubinuria, increased urinary urobilinogen & a
raised serum AST & ALT. Within 4 weeks his symptoms had completely
subsided.
5. A 55yr old woman presents with a
short Hx of nausea and abdominal pain; tender hepatomegaly and ascities. LFTs
show mildly raised transaminases, bilirubin and normal alk phos. The woman also
had polycythaemia rubra vera. Liver biopsy suggests
venous outflow obstruction.
ANSWERS
|
1. H |
2. B |
3. F |
4. E |
5. A |