Pathology EMQ.

Name: Karen Cheung-Hing

Theme: Cerebrovascular disease 2

OPTION LIST

A	Alpha-synuclein	I	Senile plaques
B	Axonal damage	J	Acromegaly
C	Demyelination	K	Ischaemic changes
D	Hypoxic cell changes	L	Senile atrophy
E	Lewy bodies	M
F	Neurofibrillary tangles (NFT)	N
G	Neurophil threads	O
H	Pick’s bodies	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 27-year old Caucasian female complains of fatigue and blurry vision. She feels as though her arms have lost strength, and sometimes they have pins-and-needles.

2. A 6-year old boy is brought to A&E following a seizure. His parents say that they have been having difficulty understanding his speech recently, and that he has been unusually aggressive towards his classmates this term. His symptoms may be helped by administering ‘Lorenzo’s Oil’.

3. The post-mortem brain of a 70-year old man shows severe atrophy, particularly in the hippocampus. Microscopic examination reveals this particular intracellular inclusion, which is in double-helix form and stains for phosphorylated tau.

4. A 56-year old man has a resting tremor that comes and goes. When you see him in the morning he dribbles and doesn’t talk to you, but in the afternoon he is doing The Times cryptic crossword! He also has very vivid hallucinations.

5. A 45-year old man presents with a resting tremor. He is worried because his family has a long history of a shaking disease. He is likely to have a mutation that affects ________?

ANSWERS

1. C

2. C

3. F

4. E

5. A