Pathology EMQ template

YourName: Saika Hussain

YourIdentifier:

Theme: Haemolytic anaemia

OPTION LIST

A	α-thalassaemia	I	malaria
B	Sickle cell disease	J	Β-thalassaemia major
C	Autoimmune haemolytic anaemia	K	G6PD Deficiency
D	Hereditary elliptocytosis	L
E	Β-thalassaemia intermedia	M
F	Paroxysmal nocturnal haemoglobinuria	N
G	Pyruvate kinase deficiency	O
H	Hereditary spherocytosis	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. Jack is a 25 year old man who presents with jaundice. On examination he has a leg ulcer and splenomegaly. After investigation he is found to have a deficiency of the structural membrane protein spectrin.

2. Duniya presents at only 6 months old with a chest infection. Her mother complains this is her 7^th infection since his birth and that she seems to be smaller than other babies of the same age. On examination she appears to have an enlarged maxilla and prominent frontal and parietal bones. Blood tests reveal a severe anaemia.

3. A substitution of the amino acid valine for glutamic acid normally present in position 6 of the beta chain of Hb.

4. Haemolysis precipitated by the ingestion of fava beans and sulphonamides.

5. Arjun visits his GP complaining of tiredness and yellow eyes. Blood tests reveal he is anaemic. Spherocytes are present on the blood film. Direct Coomb’s test is positive.

ANSWERS

1. H

2. J

3. B

4. K

5. C