Name: Michelle Camarata

Candidate number: 00391066

Theme: Chronic Myeloid Leukaemia

OPTION LIST

A	Chromosome 22q9 deletion	I	Is higher in children than in adults
B	A novel oncoprotein with tyrosine kinase activity	J	Enlarged, rubbery, non-tender nodes
C	α-interferon	K	Reed-Sternberg cells
D	Auer rods	L	Splenomegaly
E	Is highest in middle age	M	Proliferation of myeloid cells
F	Allogeneic bone marrow transplantation	N	Imatinib
G	Increased cell cycling and failure of apoptosis	O	Fusion of chromosome 22q with material from chromosome 9
H	Chromosome 13q14 translocation	P	Decreased cell cycling and increased apoptosis

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. The incidence of CML

2. The mutation that results in a novel gene that is transcribed into the BCR-ABL oncoprotein.

3. This treatment acts by inhibiting the BCR-ABL oncoprotein

4. The first line treatment for patients with newly diagnosed chronic myeloid leukaemia

5. A common clinical sign in patients with CML

ANSWERS

1. E

2. O

3. N

4. N

5. L