Pathology EMQ template.

Name: Caitríona M^cCarthy

Candidate number:

Theme: Metabolic bone histopathology

OPTION LIST

A	Compact bone	I	RANKkß
B	Cancellous bone	J	TGFß
C	Osteoblasts	K	Woven bone
D	Osteoporosis	L
E	Osteoprotegerin	M
F	Paget’s Disease	N
G	PDGF	O
H	Primary hyperparathyroidism	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. Osteoclast differentiation is regulated via this gene product

2. A 55year old male has a routine blood test following a routine check-up at his GP surgery. He is fit and well and although does admit to suffering from occasional headaches but nothing severe enough to have been a cause for worry. The results show a raised serum ALP but normal calcium and phosphate levels.

3. Primary function is mechanical support and protection.

4. A member of the tumour necrosis factor receptor superfamily resulting in osteoclast dysfunction when present at high levels.

5. A 60 year old lady presents to A&E with a humeral fracture after tripping up on an irregular pavement. A couple of years ago she underwent a kidney transplant operation and continues to be seen in the renal clinic where her glucocorticoid treatment is monitored.

ANSWERS

1. I

2. F

3. A

4. E

5. D