Pathology EMQ template.

Name: Alex Hrycaiczuk

Candidate number:

Theme: Haemolytic Anaemia

OPTION LIST

A	PK deficiency	I	Malaria
B	Paroxysmal cold haemoglobinuria	J	α-thalassaemia
C	Gilbert’s syndrome	K	G6DP deficiency
D	Sickle cell anaemia	L	Haemosiderinuria
E	Hereditary spherocytosis	M	Hereditary pyropoikilocytosis
F	β-thalassaemia major	N	Hereditary elliptocytosis
G	Microangiopathic haemolytic anaemia	O
H	Haemoglobinuria	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 22 year old male presents with jaundice and splenomegaly following a summer holiday to Malia. Following splenectomy and folate supplementation the patient became asymptomatic.

2. A 17 year old girl of African descent presents to her doctor with a sore throat. She is prescribed penicillin however returns 3 days later complaining that the drug has given her dark coloured urine.

3. A 40 year old vagrant presented to A&E with blood in his urine after waking up following an 8” overnight snowfall. He denies drinking or trauma.

4. A point mutation on the 11^th chromosome where glutamic acid is replaced by valine at the 6^th position causes this condition.

5. A girl is taken to her GP by her mother for the 9 week baby check. The mother states that the pregnancy went well with no complications yet she has noticed that her daughter is not feeding well and often appears pale. On measurement the GP notes that the girl has crossed the centriles falling from the 50^th at birth for height and weight to the 9^th on both. Her mother wonders whether this may have been caused by a recent holiday to Cyprus to see the grandparents.

ANSWERS

1. E

2. K

3. B

4. D

5. F